Change-Plane Analysis for Subgroup Detection and Sample Size Calculation
نویسندگان
چکیده
منابع مشابه
Change-Plane Analysis for Subgroup Detection and Sample Size Calculation.
We propose a systematic method for testing and identifying a subgroup with an enhanced treatment effect. We adopts a change-plane technique to first test the existence of a subgroup, and then identify the subgroup if the null hypothesis on non-existence of such a subgroup is rejected. A semiparametric model is considered for the response with an unspecified baseline function and an interaction ...
متن کاملSample Size Calculation to Evaluate Mediation Analysis
Mediation analysis is used to review the comparative change in the amount of strength of association of the primary predictor with the outcome after adjustment for the mediator. Mediation models are very widely used in social sciences and biomedical sciences. Before conducting mediation studies, researchers want to know the sample size (i.e. number of subjects) required for achieving the adequa...
متن کاملSample Size Calculation for Comparing Means
Sample size calculation plays an important role in clinical research. In clinical research, a sufficient number of patients is necessary to ensure the validity and the success of an intended trial. From a statistical point of view, if a clinically meaningful difference between a study treatment and a control truly exists, such a difference can always be detected with an arbitrary power as long ...
متن کاملSample Size Calculation for Comparing Proportions
In clinical research, in addition to continuous responses, primary clinical endpoints for assessment of efficacy and safety of a drug product under investigation could be binary responses. For example, in cancer trials, patients’ clinical reaction to the treatment is often classified as response (e.g., complete response or partial response) or nonresponse. Based on these binary responses, the p...
متن کاملSample Size Calculation for Comparing Variabilities
In practice, the variabilities of responses involved in clinical research can be roughly divided into three categories. They are, namely, intra-subject, inter-subject, and total variabilities (1). More specifically, the intrasubject variability is the variability observed by repeated measurements on the same subject under exactly the same experiment conditions. This type of variability is very ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the American Statistical Association
سال: 2017
ISSN: 0162-1459,1537-274X
DOI: 10.1080/01621459.2016.1166115